A double-blind, placebo-controlled study of sucrose polyester in hypercholesterolemic outpatients
| Autor: | J D Taulbee, G E Lamkin, Ronald J. Jandacek, A Gouge, P King, M J Mellies, Charles J. Glueck, S Goldman, M B Tewksbury, D Boggs, Reginald C. Tsang, L Baehler |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Sucrose Olestra medicine.medical_treatment Saturated fat Lipoproteins Hypercholesterolemia Placebo-controlled study Medicine (miscellaneous) Placebo Drug Administration Schedule Double blind chemistry.chemical_compound Animal science Double-Blind Method Outpatients medicine Humans Sucrose polyester Triglycerides Aged Clinical Trials as Topic Nutrition and Dietetics Cholesterol business.industry Anticholesteremic Agents Fatty Acids Vitamins Middle Aged chemistry Female business Energy Intake Olive oil |
| Zdroj: | The American journal of clinical nutrition. 37(3) |
| ISSN: | 0002-9165 |
| Popis: | Sucrose polyester (SPE) was studied in a double-blind, placebo-controlled trial in 91 outpatients with primary hypercholesterolemia. All patients maintained an isocaloric diet with cholesterol intake of 400 mg/day and a polyunsaturated to saturated fat ratio of 0.8 to 1.2 for the duration of the study. The study sequence consisted of a diet lead-in period, a first 8-wk treatment period, a 4-wk washout period, and a second 8-wk treatment period. Subjects were randomly assigned to six groups that differed by SPE dose (8, 16, and 32 g/day) and by the treatment period in which either SPE or an olive oil placebo was given in a bread spread formulation. Compared to placebo, the 8, 16, and 32 g/day doses of SPE decreased low-density lipoprotein cholesterol by 2%, 4% (p less than 0.05), and 5% (p less than 0.05) respectively, without changing high-density lipoprotein cholesterol. On SPE, 14/91 (15%) of the subjects experienced a decrease in low-density lipoprotein cholesterol greater than or equal to 10%, while only 2/91 (2%) showed this decrease with placebo. |
| Databáze: | OpenAIRE |
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