Optimized synthesis and crystalline stability of γ-cyclodextrin metal-organic frameworks for drug adsorption
| Autor: | Jiwen Zhang, Xue Li, Ruxandra Gref, Haiyan Li, Botao Liu, Xu Xu, Nana Lv, Peter York, J. Fraser Stoddart, Vikramjeet Singh, Xiaonan Xu |
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| Rok vydání: | 2016 |
| Předmět: |
Hot Temperature
Diffusion Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences Crystallinity Drug Delivery Systems Adsorption Pulmonary surfactant Organometallic Compounds Organic chemistry Particle Size Porosity chemistry.chemical_classification Cyclodextrin Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent Chemical engineering Metals Solvents Metal-organic framework 0210 nano-technology gamma-Cyclodextrins |
| Zdroj: | International Journal of Pharmaceutics. 514:212-219 |
| ISSN: | 0378-5173 |
| Popis: | The biocompatible and renewable cyclodextrin metal-organic frameworks (CD-MOFs) have addressed a range of opportunities in molecular storage and separation sciences. The reported protocols for their synthesis, however, were carried out at room temperature over long time periods of time (24h), producing crystals of relatively poor uniformity. In this investigation, micron sized γ-CD-MOFs were synthesized by an optimized vapor diffusion method at elevated temperature (50°C) within 6h, after which the size control, crystalline stability and drug adsorption behavior were investigated in detail. In this manner, uniform cubic γ-CD-MOF crystals were obtained when the reaction temperature was raised to 50°C with pre-addition of the reaction solvent. The size of γ-CD-MOFs was adjusted efficiently by changing the reactant concentrations, temperatures, time, γ-CD ratios to KOH and surfactant concentrations, without influencing the porosity and crystallinity of the material markedly. Varing degrees of reduction in crystallinity and change in morphology were observed when the γ-CD-MOF crystals are treated under conditions of high temperature (100°C), high humidity (92.5%) and polar solvents (e.g., MeOH and DMF). In relation to drug adsorption by γ-CD-MOFs, most of the drug molecules containing carboxyl groups showed relatively high adsorption (>5%), while low adsorption ( |
| Databáze: | OpenAIRE |
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