In vitro and in vivo evaluation of microneedles coated with electrosprayed micro/nanoparticles for medical skin treatments

Autor:	Necibe Basaran Mutlu Agardan, Serdar Tort, Andrew J. Steckl, Daewoo Han
Rok vydání:	2020
Předmět:	Chemistry Organic Chemistry Skin treatments Pharmaceutical Science Nanoparticle Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy In vitro 03 medical and health sciences 0302 clinical medicine Colloid and Surface Chemistry Functional importance In vivo Drug delivery Micro nanoparticles Physical and Theoretical Chemistry 0210 nano-technology Layer (electronics) Biomedical engineering
Zdroj:	Journal of Microencapsulation. 37:517-527
ISSN:	1464-5246 0265-2048
DOI:	10.1080/02652048.2020.1809725
Popis:	Aim Microneedles (MNs) create micropunctures and deliver drugs or nutrients deep into skin layer. We demonstrated that MNs, coated with electrosprayed nanoparticles loaded with functional molecules, are useful for transdermal delivery. Methods Electrospraying was utilised to generate drug-loaded nanoparticles and to create uniform coating on MNs. Process parameters and release kinetics were evaluatedin vitro.Thein vivoefficacy of insulin-coated MNs was investigated using diabetic rats. Results Electrosprayed micro/nanoparticles loaded with dye or insulin were coated on MNs with particle size of 515 +/- 286 and 522 +/- 261 nm, respectively. Optimally coated MNs resulted in >70% transfer rate into porcine skins. Insulin-coated MNs were applied to diabetic rats resulting in reduction of blood glucose levels fluctuations, compared to subcutaneous injections. Conclusions Electrospraying is shown to be an effective method to coat MNs with drug-loaded nanoparticles. Coated MNs provide a promising platform for cosmetic, drug and protein delivery applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4c04d7faa4078e23eb6fefd3f73bea https://doi.org/10.1080/02652048.2020.1809725 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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