Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities

Autor: Donita Lightner, Elizabeth R. Wallace, K. L. Van Pelt, Amelia J. Anderson-Mooney, Lisa M. Koehl, Elizabeth Head, William C. Robertson, Allison Caban-Holt, Jordan P. Harp, Frederick A. Schmitt, Greg Jicha
Rok vydání: 2021
Předmět:
cognition
Adult
Aging
Down syndrome
Intellectual and Developmental Disabilities (IDD)
Population
Disease
Neurodegenerative
Neuropsychological Tests
Alzheimer's Disease
Medical and Health Sciences
Article
Education
Arts and Humanities (miscellaneous)
Clinical Research
Alzheimer Disease
Behavioral and Social Science
mental disorders
Acquired Cognitive Impairment
Humans
Medicine
Dementia
Medical diagnosis
education
education.field_of_study
Receiver operating characteristic
Learning Disabilities
business.industry
Psychology and Cognitive Sciences
Rehabilitation
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Cognition
medicine.disease
Brain Disorders
Psychiatry and Mental health
Cross-Sectional Studies
Neurology
Neurological
Learning disability
Mental health
Neurology (clinical)
Down Syndrome
medicine.symptom
business
Clinical psychology
Zdroj: J Intellect Disabil Res
Journal of intellectual disability research : JIDR, vol 65, iss 12
ISSN: 1365-2788
0964-2633
DOI: 10.1111/jir.12901
Popis: BackgroundIndividuals with Down syndrome (DS) are at high risk for dementia, specifically Alzheimer's disease. However, many measures regularly used for the detection of dementia in the general population are not suitable for individuals with DS due in part to floor effects. Some measures, including the Severe Impairment Battery (SIB), Brief Praxis Test (BPT) and Dementia Scale for People with Learning Disabilities (DLD), have been used in clinical trials and other research with this population. Validity research is limited, particularly regarding the use of such tools for detection of prodromal dementia in the DS population. The current project presents baseline cross-sectional SIB, BPT and DLD performance in order to characterise their predictive utility in discriminating normal cognition, possible dementia and probable dementia in adult DS.MethodBaseline SIB, BPT and DLD performances from 100 individuals (no dementia=68, possible dementia=16 & probable dementia=16) were examined from a longitudinal cohort of aging individuals with DS. Receiver operating characteristic curves investigated the accuracy of these measures in relation to consensus dementia diagnoses, diagnoses which demonstrated high percent agreement with the examining neurologist's independent diagnostic impression.ResultsThe SIB and BPT exhibited fair discrimination ability for differentiating no/possible versus probable dementia [area under the curve (AUC)=0.61 and 0.66, respectively]. The DLD exhibited good discrimination ability for differentiating no versus possible/probable dementia (AUC=0.75) and further demonstrated better performance of the DLD Cognitive subscale compared with the DLD Social subscale (AUC=0.77 and 0.67, respectively).ConclusionsResults suggest that the SIB, BPT and DLD are able to reasonably discriminate consensus dementia diagnoses in individuals with DS, supporting their continued use in the clinical assessment of dementia in DS. The general performance of these measures suggests that further work in the area of test development is needed to improve on the AUCs for dementia status discrimination in this unique population. At present, however, the current findings suggest that the DLD may be the best option for reliable identification of prodromal dementia in this population, reinforcing the importance of including informant behaviour ratings in assessment of cognition for adults with DS.
Databáze: OpenAIRE
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