A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013
| Autor: | H Nishimura, Emi Takashita, Takato Odagiri, M Miura, R Itoh, A Ohnishi, Miho Ejima, Masato Tashiro |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Oseltamivir Epidemiology viruses Molecular Sequence Data Acids Carbocyclic Neuraminidase Cyclopentanes Microbial Sensitivity Tests Drug resistance medicine.disease_cause Antiviral Agents Guanidines Virus Microbiology chemistry.chemical_compound Influenza A Virus H1N1 Subtype Japan Virology Drug Resistance Viral Influenza Human medicine Influenza A virus Humans Child Phylogeny Cross-resistance biology Public Health Environmental and Occupational Health Infant virus diseases Sequence Analysis DNA Treatment Outcome Specimen collection chemistry Child Preschool DNA Viral Mutation biology.protein Female Peramivir medicine.drug |
| Zdroj: | Eurosurveillance. 19 |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/1560-7917.es2014.19.1.20666 |
| Popis: | Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could be identified; none of them had received neuraminidase inhibitors before specimen collection. The haemagglutinin and neuraminidase genes of the six viruses were closely related to one another, suggesting clonal spread of a single resistant virus. |
| Databáze: | OpenAIRE |
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