Leucocytoclastic vasculitis in severe ulcerative colitis
| Autor: | Tristan Handler, Joseph McDermott, Donald G. Martin |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Adrenal Cortex Hormones medicine Humans Colitis skin and connective tissue diseases Mesalamine Colectomy Erythema nodosum integumentary system business.industry Anti-Inflammatory Agents Non-Steroidal Public Health Environmental and Occupational Health Antibodies Monoclonal General Medicine medicine.disease Dermatology Ulcerative colitis Infliximab Surgery Clinical research Military Personnel Concomitant Vasculitis Leukocytoclastic Cutaneous Colitis Ulcerative Dermatologic Agents business Pyoderma gangrenosum medicine.drug |
| Zdroj: | Military medicine. 176(5) |
| ISSN: | 0026-4075 |
| Popis: | Ulcerative colitis may be associated with a number of extraintestinal skin manifestations including erythema nodosum and pyoderma gangrenosum. We describe an unusual case of a 26-year-old military pilot with ulcerative colitis and skin lesions diagnosed as leucocytoclastic vasculitis. The skin lesions occurred twice during the severe flare. The first occurrence was treated successfully with corticosteroids. When the lesions recurred several weeks later, concomitant with the ongoing flare, treatment with mesalamine and infliximab resolved the lesions. Ultimately, the patient required total colectomy for flare unresponsive to maximum medical therapy. The leucocytoclastic vasculitis did not recur after colectomy. We propose a potential immunopathophysiologic mechanism linking the 2 conditions based on recent biochemical and clinical research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|