Impaired Respiratory Health and Life Course Transitions From Health to Chronic Lung Disease
| Autor: | Gabrielle Y. Liu, Ravi Kalhan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
Pulmonary and Respiratory Medicine medicine.medical_specialty Physical fitness Life Course Perspective Disease Critical Care and Intensive Care Medicine Tobacco smoke 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Risk Factors medicine Humans COPD: CHEST Reviews 030212 general & internal medicine Intensive care medicine Life Style COPD Lung business.industry Interstitial lung disease respiratory system medicine.disease Causality medicine.anatomical_structure 030228 respiratory system Asymptomatic Diseases Chronic Disease Life course approach Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Chest |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2021.04.009 |
| Popis: | Primary prevention and interception of chronic lung disease are essential in the effort to reduce the morbidity and mortality caused by respiratory conditions. In this review, we apply a life course approach that examines exposures across the life span to identify risk factors that are associated with not only chronic lung disease but also an intermediate phenotype between ideal lung health and lung disease, termed "impaired respiratory health." Notably, risk factors such as exposure to tobacco smoke and air pollution, as well as obesity and physical fitness, affect respiratory health across the life course by being associated with both abnormal lung growth and lung function decline. We then discuss the importance of disease interception and identifying those at highest risk of developing chronic lung disease. This work begins with understanding and detecting impaired respiratory health, and we review several promising molecular biomarkers, predictive symptoms, and early imaging findings that may lead to a better understanding of this intermediate phenotype. |
| Databáze: | OpenAIRE |
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