Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives

Autor:	Andrzej Olczak, Tomasz Pawlak, Sylwia Kałużyńska, Katarzyna Gobis, Izabela Korona-Głowniak, Katarzyna Suśniak, Marcin Zaborowski, Małgorzata Szczesio
Rok vydání:	2023
Předmět:	Inorganic Chemistry Organic Chemistry 1H-benzo[d]imidazole derivatives antimicrobial activity structure–activity relationship X-ray ADME crossing the blood–brain barrier General Medicine Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications
Zdroj:	International Journal of Molecular Sciences; Volume 24; Issue 4; Pages: 3319
ISSN:	1422-0067
DOI:	10.3390/ijms24043319
Popis:	Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e42858a76804198d054bb168cef7363 https://doi.org/10.3390/ijms24043319 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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