Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India
| Autor: | Mahesh M. Kumar, Harish Thippeswamy, Reeta S. Mani, Prabha S. Chandra, Gopinath Sathyanarayanan, Manjunatha M. Venkataswamy |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Hospitals Psychiatric 0301 basic medicine Myeloid Immunology India CD11c chemical and pharmacologic phenomena medicine.disease_cause Monocytes Immunophenotyping Young Adult 03 medical and health sciences 0302 clinical medicine Immune system T-Lymphocyte Subsets medicine Humans Immunology and Allergy Cytotoxic T cell Tertiary Healthcare business.industry Postpartum Period Dendritic Cells Immune dysregulation Flow Cytometry medicine.disease Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Immune System Diseases Psychotic Disorders Neurology Cytokines Female Neurology (clinical) Postpartum psychosis business 030217 neurology & neurosurgery CD8 |
| Zdroj: | Journal of Neuroimmunology. 310:8-13 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2017.06.002 |
| Popis: | Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T cells, while activated CD8 and memory regulatory T cells (Tregs) were increased in women with PP as against healthy controls. The CD14-CD16+non-classical monocytes, CD11c+myeloid DCs and cytotoxic CD56dimCD16+ were reduced, while CD56brtCD16+/-regulatory NK cells were elevated in women with PP. The variations in immune cell subsets highlight the generalized immune dysregulation in PP. |
| Databáze: | OpenAIRE |
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