Effective approaches to discover new microbial metabolites in a large strain library
| Autor: | Guadalupe S. Zarazúa, Marianna Iorio, Arianna Tocchetti, Mitja M Zdouc, Margherita Sosio, Cristina Brunati, Matteo Simone, Stefania Serina, Kristiina Vind, Max Crüsemann, Paolo Monciardini, Stefano Donadio, Sonia I. Maffioli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biomedical Research
Microbial diversity Drug Evaluation Preclinical Bioengineering Computational biology 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences Antibiotics Pseudouridimycin Actinomycetes Animals Humans Host-Microbe Interactomics Streptomyces strain Planomonospora Microbial metabolite Gene Library 030304 developmental biology VLAG Biological Products 0303 health sciences Bacteria 010405 organic chemistry New RiPP family Streptomyces 0104 chemical sciences 3. Good health Large strain Biotechnology |
| Zdroj: | Journal of Industrial Microbiology and Biotechnology Journal of Industrial Microbiology and Biotechnology, 48(3-4) Journal of Industrial Microbiology and Biotechnology 48 (2021) 3-4 |
| ISSN: | 1367-5435 |
| Popis: | Natural products have provided many molecules to treat and prevent illnesses in humans, animals and plants. While only a small fraction of the existing microbial diversity has been explored for bioactive metabolites, tens of thousands of molecules have been reported in the literature over the past 80 years. Thus, the main challenge in microbial metabolite screening is to avoid the re-discovery of known metabolites in a cost-effective manner. In this perspective, we report and discuss different approaches used in our laboratory over the past few years, ranging from bioactivity-based screening to looking for metabolic rarity in different datasets to deeply investigating a single Streptomyces strain. Our results show that it is possible to find novel chemistry through a limited screening effort, provided that appropriate selection criteria are in place. |
| Databáze: | OpenAIRE |
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