Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility
Autor: | Sigrid Botne Sando, Minerva M. Carrasquillo, Michael Crump, Oliver J. Culley, Li Ma, Talisha A. Hunter, Gina Bisceglio, Fanggeng Zou, Dennis W. Dickson, Linda H. Younkin, Ronald C. Petersen, Jan O. Aasly, Ferenc Deak, Olivia Belbin, Mariet Allen, Neill R. Graff-Radford, Sebastian Carrasquillo, Daniel Sevlever |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
Vesicle-Associated Membrane Protein 1 Clinical Neurology Biology Exocytosis Cellular and Molecular Neuroscience Mice Alzheimer Disease Internal medicine medicine Animals Humans Genetic Predisposition to Disease Genetic Testing Receptor Molecular Biology Gene knockdown VAMP1 Amyloid beta-Peptides β-amyloid Alzheimer's disease medicine.disease Molecular medicine Synapse 3. Good health Endocrinology Vesicle-associated membrane protein Membrane protein SNARE Vesicle-Associated Membrane Protein 1 β-amyloid Alzheimer’s disease Synapse SNARE Immunology Synapses Neurology (clinical) Erratum Alzheimer’s disease Research Article |
Zdroj: | Molecular Neurodegeneration Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
ISSN: | 1750-1326 |
Popis: | Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. Since proteins in the SNAP (Soluble N-ethylmaleimide-sensitive factor Attachment Protein) REceptors (SNARE) complex are essential for neuronal Aβ release at pre-synaptic terminals, we hypothesized that genetically controlled SNARE expression could alter neuronal Aß release at the synapse and hence play an early role in Alzheimer’s pathophysiology. Results Here we report 5 polymorphisms in Vesicle-Associated Membrane Protein 1 (VAMP1), a gene encoding a member of the SNARE complex, associated with bidirectionally altered cerebellar VAMP1 transcript levels (all p |
Databáze: | OpenAIRE |
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