Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility

Autor: Sigrid Botne Sando, Minerva M. Carrasquillo, Michael Crump, Oliver J. Culley, Li Ma, Talisha A. Hunter, Gina Bisceglio, Fanggeng Zou, Dennis W. Dickson, Linda H. Younkin, Ronald C. Petersen, Jan O. Aasly, Ferenc Deak, Olivia Belbin, Mariet Allen, Neill R. Graff-Radford, Sebastian Carrasquillo, Daniel Sevlever
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Molecular Neurodegeneration
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 1750-1326
Popis: Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. Since proteins in the SNAP (Soluble N-ethylmaleimide-sensitive factor Attachment Protein) REceptors (SNARE) complex are essential for neuronal Aβ release at pre-synaptic terminals, we hypothesized that genetically controlled SNARE expression could alter neuronal Aß release at the synapse and hence play an early role in Alzheimer’s pathophysiology. Results Here we report 5 polymorphisms in Vesicle-Associated Membrane Protein 1 (VAMP1), a gene encoding a member of the SNARE complex, associated with bidirectionally altered cerebellar VAMP1 transcript levels (all p
Databáze: OpenAIRE
načítá se...