Antimicrobial compounds from Ceanothus americanus against oral pathogens
| Autor: | Christine D. Wu, Xing-Cong Li, Lining Cai |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Actinomyces viscosus
Magnetic Resonance Spectroscopy Flavonoid Microbial Sensitivity Tests Plant Science Horticulture Prevotella intermedia Biochemistry Mass Spectrometry Ceanothus americanus Microbiology Streptococcus mutans chemistry.chemical_compound Glucosides Glucoside Molecular Biology Benzofurans chemistry.chemical_classification Mouth Plants Medicinal Molecular Structure biology Actinomycetaceae General Medicine Antimicrobial biology.organism_classification Anti-Bacterial Agents chemistry Norsteroids Porphyromonas gingivalis Bacteria |
| Zdroj: | Phytochemistry. 46:97-102 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/s0031-9422(97)00222-7 |
| Popis: | During the search for antimicrobial compounds from higher plant sources, a methanol extract of Ceanothus americanus demonstrated antimicrobial activity against selected oral pathogens. Through further bioassay-guided fractionation and purification, three triterpenes (ceanothic acid, 27-hydroxy ceanothic acid and ceanothetric acid) and two flavonoids (maesopsin and maesopsin-6-O-glucoside) were identified. Among these, ceanothetric acid and maesopsin-6-O-glucoside were new compounds. Ceanothic acid and ceanothetric acid demonstrated growth inhibitory effect against Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia with MICs ranging from 42 to 625 micrograms ml-1. Maesopsin, its glucoside, and 27-hydroxy ceanothic acid, were inactive below the concentration of 500 micrograms ml-1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect