Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
| Autor: | Sanzhong Xu, Zhong Chen, Xiangjin Lin, Xianfeng Lou, Junhua Du, Xigong Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
functional recovery Inflammation lcsh:RC346-429 anti-inflammatory agents rosiglitazone 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Developmental Neuroscience medicine Receptor nerve regeneration spinal cord injury methylprednisolone inflammation drug therapy neural regeneration Spinal cord injury lcsh:Neurology. Diseases of the nervous system business.industry Spinal cord medicine.disease 030104 developmental biology medicine.anatomical_structure Methylprednisolone Apoptosis Anesthesia medicine.symptom business Rosiglitazone 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, Vol 11, Iss 10, Pp 1678-1684 (2016) |
| ISSN: | 1876-7958 1673-5374 |
| Popis: | Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages of secondary spinal cord injury. Because of the complexity and diversity of the inflammatory process after spinal cord injury, a single drug cannot completely inhibit inflammation. Therefore, we assumed that a combination of methylprednisolone and rosiglitazone might promote recovery of neurological function after secondary spinal cord injury. In this study, rats were intraperitoneally injected with methylprednisolone (30 mg/kg) and rosiglitazone (2 mg/kg) at 1 hour after injury, and methylprednisolone (15 mg/kg) at 24 and 48 hours after injury. Rosiglitazone was then administered once every 12 hours for 7 consecutive days. Our results demonstrated that a combined treatment with methylprednisolone and rosiglitazone had a more pronounced effect on attenuation of inflammation and cell apoptosis, as well as increased functional recovery, compared with either single treatment alone, indicating that a combination better promoted recovery of neurological function after injury. |
| Databáze: | OpenAIRE |
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