Properties of a brief assessment tool for longitudinal measurement of cognition in people living with HIV

Autor: Lesley K. Fellows, Réjean Thomas, Lois Finch, Nancy E. Mayo, Marie-Josée Brouillette
Jazyk: angličtina
Rok vydání: 2019
Předmět:
RNA viruses
Male
AIDS Dementia Complex
Psychometrics
Emotions
Social Sciences
HIV Infections
Anxiety
Neuropsychological Tests
Pathology and Laboratory Medicine
0302 clinical medicine
Cognition
Learning and Memory
Immunodeficiency Viruses
Medicine and Health Sciences
Psychology
030212 general & internal medicine
Longitudinal Studies
Cognitive Impairment
Multidisciplinary
Cognitive Neurology
Middle Aged
Neurology
Medical Microbiology
Viral Pathogens
Viruses
Memory Recall
Medicine
Female
Pathogens
Research Article
Adult
medicine.medical_specialty
Elementary cognitive task
Cognitive Neuroscience
Science
Cognitive neuroscience
Microbiology
03 medical and health sciences
Fluency
Physical medicine and rehabilitation
Memory
Neuropsychology
Retroviruses
medicine
Humans
Cognitive Dysfunction
Set (psychology)
Microbial Pathogens
Neuropsychological Testing
Rasch model
Recall
Lentivirus
Organisms
Cognitive Psychology
Biology and Life Sciences
HIV
Cognitive Science
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 14, Iss 3, p e0213908 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: Background Mild cognitive impairment is common in chronic HIV infection and there is concern that it may worsen with age. Distinguishing static impairment from on-going decline is clinically important, but the field lacks well-validated cognitive measures sensitive to decline and feasible for routine clinical use. Measures capable of detecting improvement are also needed to assess interventions. The objective of this study is to estimate the extent of change on repeat administration of three different forms of a brief computerized cognitive assessment battery (B-CAM) developed for assessing cognitive ability in the mildly-impaired to normal range in people living with HIV. We hypothesized no change over a six-month period in people on effective antiretroviral therapy. Methods 102 HIV+ individuals completed a set of computerized cognitive tasks on three occasions over a six-month period. Rasch analysis was used to determine if change over time (i.e. improvement due to practice) was uniform across tasks and to refine scoring in order to produce three forms of the B-CAM of equivalent level of difficulty. Group-based trajectory analysis (GBTA) was then applied to determine if performance at baseline influenced the magnitude of practice-related improvement on the battery as a whole over the course of follow-up. Results Two cognitive tasks (fluency and word recall) had different levels of difficulty across test sessions, related to the different forms of the tasks. These two items were split by testing session. For all other items, the level of difficulty remained constant across all three time points. GBTA showed that the sample was composed of three distinct groups of people with unique trajectories, defined mainly by level of cognitive ability at baseline. Only the highest group showed an apparent improvement over time, but this change fell within measurement error. Conclusions Rasch analysis provides mathematical confirmation that these three forms of the B-CAM are of equivalent difficulty. GBTA demonstrates that no adjustment of the total score is required to correct for practice effects. Application of these modern statistical methods paves the way towards rapid and robust quantification of change in cognition.
Databáze: OpenAIRE
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