| Přispěvatelé: |
[Sánchez-Díaz,M, Salvador-Rodríguez,L, Montero-Vílchez,T, Martínez-López,A, Arias-Santiago,S, Molina-Leyva,A] Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, Granada, Spain. [Arias-Santiago,S] Dermatology Department, School of Medicine, University of Granada, Granada, Spain. [Molina-Leyva,A] Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Granada, Spain. |
| Popis: |
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study
the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk. |
