Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution
| Autor: | Xin Wei Wang, Lichun Ma, Amanda J. Craig, Subreen Khatib |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell type Hepatology Liver cell Liver Neoplasms Context (language use) Computational biology Disease Biology Chronic liver disease medicine.disease Review article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Hepatocytes medicine Humans Liver cancer Reprogramming |
| Zdroj: | Seminars in Liver Disease. 41:321-330 |
| ISSN: | 1098-8971 0272-8087 |
| Popis: | Single-cell technologies are revolutionizing our understanding of cellular heterogeneity and functional diversity in health and disease. Here, we review the current knowledge and advances in liver biology using single-cell approaches. We focus on the landscape of the composition and the function of cells in a healthy liver in the context of its spatial organization. We also highlight the alterations of the molecular landscape in chronic liver disease and liver cancer, which includes the identification of disease-related cell types, altered cellular functions, dynamic cell–cell interactions, the plasticity of malignant cells, the collective behavior of a cell community, and microenvironmental reprogramming. We anticipate that the uncovered liver cell atlas will help deciphering the molecular and cellular mechanisms driving a healthy liver into a disease state. It also offers insight into the detection of new therapeutic targets and paves the way for effective disease interventions. |
| Databáze: | OpenAIRE |
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