| Autor: |
Minhong Yan, Jayme Franklin, Philip E. Hass, Maciej Paluch, John Brady Ridgway, Jane Ruppel, Siao Ping Tsai, Ryan Cook, Sarajane Ross, Sharon Yee, Gary Cain, Krishna P. Allamneni, Jacqueline Tarrant, Nicholas Lewin-Koh, Amrita V. Kamath, Priyanka Gupta, Christina L. Zuch de Zafra, Joseph C. Beyer, Gu Zhang, Jessica A. Couch |
| Rok vydání: |
2023 |
| Popis: |
Supplemental Methods: including HUVEC fibrin gel bead assay, Production of anti-DLL4 F(ab')2, Mouse neonatal retina assay, Xenograft tumor models, Histological analysis of mouse liver, PK assay methods, and Anti-therapeutic antibody assay method. Table S1: PK parameters of anti-DLL4 IgG1 and F(ab')2 in mouse. Table S2: PK parameters for anti-DLL4 IgG1 and F(ab')2 in rat and money. Table S3: Summary of incidence of skin neoplasms in rats treated with anti-DLL4 IgG1 or anti-DLL4 F(ab')2. Figure S1: Generating and characterizing low affinity anti-DLL4 antibodies. Figure S2: Characterization of anti-DLL4 F(ab')2 using HUVEC bead sprouting assay. Figure S3: PK profile of anti-DLL4 IgG1 and F(ab')2 in rat toxicity studies. Figure S4. Mitigation of liver toxicity in mice with anti-DLL4 F(ab')2. Figure S5. Novel toxicities identified with anti-DLL4 F(ab')2 in rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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