Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
| Autor: | Simone M. Cinini, Claudio Marcos Teixeira de Queiroz, Miriam Marcela Blanco, Josy Carolina C. Pontes, Luiz E. Mello, Thiago Zaqueu Lima |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Status epilepticus Pharmacology 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures Anti-epileptic drugs medicine Animals Animal model Neuropeptide Y Pentylenetetrazol Pharmacoresistance Electrocorticography Valproic Acid medicine.diagnostic_test Pilocarpine Brain Callithrix Carbamazepine medicine.disease Immunohistochemistry Disease Models Animal 030104 developmental biology Neurology Phenobarbital Chronic Disease Pentylenetetrazole Anticonvulsants Female Neurology (clinical) medicine.symptom Psychology Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| ISSN: | 0920-1211 |
| DOI: | 10.1016/j.eplepsyres.2016.06.012 |
| Popis: | The efficiency of most of the new antiepileptic drugs (AEDs) on clinical trials still falls short the success reported in pre-clinical studies, possibly because the validity of the animal models is insufficient to fully represent the human pathology. To improve the translational value for testing AEDs, we propose the use of non-human primates. Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED. Marmosets with epileptic background were more susceptible to seizures induced by PTZ, which were at least 3 times longer and more severe (about 6 times greater frequency of generalized seizures) in comparison to naïve peers. Accordingly, PTZ-induced seizures were remarkably less attenuated by AEDs in epileptic than naïve marmosets. While phenobarbital (40 mg/kg) virtually abolished seizures regardless of the animal’s background, carbamazepine (120 mg/kg) and valproic acid (400 mg/kg) could not prevent PTZ-induced seizures in epileptic animals with the same efficiency as observed in naïve peers. VPA was less effective regarding the duration of individual seizures in epileptic animals, as assessed in ECoG (p = 0.05). Similarly following CBZ treatment, the behavioral manifestation of generalized seizures lasted longer in epileptic (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect