A case of progressive systemic sclerosis (PSS) with silent thyroiditis and anti-bovine thyrotropin antibodies
| Autor: | Yoshiyuki Fuwa, Mayumi Yamamoto, Noriyoshi Yamakita, Kenzou Chimori, Shigeki Sakata |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Systemic disease endocrine system diseases Thyrotropin Trab Thyroiditis Scleroderma Antibodies Iodine Radioisotopes Endocrinology Internal medicine Medicine Animals Humans Autoimmune disease Scleroderma Systemic biology business.industry General Engineering Clinical course Thyroiditis Autoimmune Progressive systemic sclerosis Middle Aged medicine.disease Precipitin Tests Immunology biology.protein Cattle Antibody business |
| Zdroj: | Endocrinologia japonica. 38(3) |
| ISSN: | 0013-7219 |
| Popis: | We have examined a patient with progressive systemic sclerosis (PSS) who had increased serum T3 (235 ng/dl) and T4 (13.2 micrograms/dl) and low 24-h thyroidal 123I-uptake (1.2%). A diagnosis of silent thyroiditis was made on the basis of the clinical course and laboratory and histopathologic findings. Simultaneous measurement of serum anti-thyrotropin receptor antibody (TRAb) showed a negative value (-49.0%) which suggested the presence of anti-TSH antibody. Further examination by immune precipitation with 125I-bovine TSH (bTSH) and also with 125I-human TSH (hTSH) revealed the presence of anti-bTSH antibody but not anti-hTSH antibody in his serum gamma-globulin. The significance of the association of PSS, silent thyroiditis, and anti-bTSH in one individual is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|