Calcium sensor properties for activity-dependent homeostatic regulation of pyloric network rhythms in the lobster stomatogastric ganglion
| Autor: | K Richard Hammett, Astrid A. Prinz, Cengiz Günay, Ryan M Hooper |
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| Jazyk: | angličtina |
| Předmět: |
0303 health sciences
General Neuroscience chemistry.chemical_element Stomatogastric ganglion Calcium Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Rhythm chemistry CpG site Neuroscience 030217 neurology & neurosurgery Homeostasis 030304 developmental biology |
| Zdroj: | BMC Neuroscience. 9(Suppl 1):P42 |
| ISSN: | 1471-2202 |
| DOI: | 10.1186/1471-2202-9-s1-p42 |
| Popis: | Homeostatic regulation has been proposed as a mecha-nism that can explain the robust behavior of central pat-tern generating (CPG) neural networks observedexperimentally. CPG networks, such as the pyloric net-work in the stomatogastric ganglion (STG) of the lobster,generate stable patterns of activity in spite of constantmolecular turnover and environmental changes.Although the sensing and acting components of regula-tion are not yet well understood, one likely scenario is thatcalcium-based activity sensors drive the regulation ofintrinsic cellular and synaptic properties.It has been shown that calcium can help maintain stableactivity levels in individual model neurons [1], andpyloric rhythms in one network model [2]. Remainingquestions are: (1) whether calcium sensors work in differ-ent network model versions, and (2) what intrinsic prop-erties of calcium sensors are important for distinguishingfunctional from non-functional activity patterns. |
| Databáze: | OpenAIRE |
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