DNA binding properties of DAPI (4',6-diamidino-2-phenylindole) analogs having an imidazoline ring or a tetrahydropyrimidine ring: groove-binding and intercalation
| Autor: | Kyoko Kubota, Seiji Tani, Yukio Kubota |
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| Rok vydání: | 2003 |
| Předmět: |
Binding Sites
Indoles Base Sequence Stereochemistry Intercalation (chemistry) Imidazoline receptor General Medicine DNA Dichroism In Vitro Techniques Ring (chemistry) Fluorescence eye diseases Intercalating Agents chemistry.chemical_compound chemistry Oligodeoxyribonucleotides Animals Cattle sense organs DAPI Binding site Nuclear Magnetic Resonance Biomolecular |
| Zdroj: | Nucleic acids symposium series. (44) |
| ISSN: | 0261-3166 |
| Popis: | DAPI analogs containing an imidazoline ring or a tetrahydropyrimidine ring have been synthesized to study DNA binding properties. Spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements indicate that DAPI analogs interact with DNA both by intercalation and by groove binding. The solution structures of complexes between DAPI analog and DNA oligomers have been characterized by proton NMR spectroscopy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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