Quantitative analysis of colorectal mucosal lesions by autofluorescence endoscopy: Discrimination of carcinomas from other lesions
| Autor: | Osamu Tsuruta, Yasutomo Watanabe, Yoshinobu Okabe, Keiko Arita, Hiroshi Kawano, Keiichi Mitsuyama, Michio Sata, Shin Hasegawa, Junya Masuda, Yasuhiko Maeyama, Yoshito Akagi |
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| Rok vydání: | 2011 |
| Předmět: |
Adenoma
Male Cancer Research Pathology medicine.medical_specialty Colonic Polyps Contrast Media Colonoscopy Pilot Projects Biology Lesion Image Processing Computer-Assisted medicine Humans Aged medicine.diagnostic_test Carcinoma Cancer Endoscopy Histology General Medicine Middle Aged medicine.disease Molecular medicine Autofluorescence Microscopy Fluorescence Oncology Hyperplastic Polyp Female medicine.symptom Colorectal Neoplasms |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2011.1287 |
| Popis: | A newly developed autofluorescence (AF) imaging technique was applied during colonoscopy in a clinical setting. This pilot study was conducted to evaluate the clinical feasibility of applying AF endoscopy for distinguishing colorectal lesions. A total of 54 colorectal mucosal lesions obtained from 43 patients who underwent both white-light and AF endoscopy and were treated by endoscopy or surgery were assessed. Of the lesions, 11 were hyperplastic polyps, 30 were adenomas and 13 were carcinomas. To quantify the AF intensity, a color-contrast index (CCI) was determined and evaluated in relation to the histology, size and shape of each lesion. CCI was significantly associated with the histology and size of the lesions, but not their shape. CCI increased as the malignant potential increased (in the order of hyperplastic polyps→adenomas→carcinomas), irrespective of the lesion size (r=0.797, p0.0001 for size8 mm; r=0.622, p=0.0045 for size8 mm but15 mm; r=0.644, p=0.0071 for size15 mm). In each size group, CCI tended to be higher for carcinomas than for adenomas, and also higher for adenomas than for hyperplastic polyps. CCI allowed discrimination of adenomas/carcinomas from hyperplastic polyps with 95.3% sensitivity and 63.6% specificity (cut-off value, 14.5), and of colorectal carcinomas from adenomas with 84.6% sensitivity and 80.0% specificity (cut-off value, 28.0). These results suggest that the quantitative analysis of AF intensity using CCI is helpful to discriminate among different types of colorectal mucosal lesions, including carcinomas. |
| Databáze: | OpenAIRE |
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