Performance of commercially available HIV in vitro diagnostic assays: A systematic review and meta-analysis
| Autor: | Santanu Banerjee, Malay Kumar Saha, Mihir Bhatta, Srijita Nandi, Shanta Dutta |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty Receiver operating characteristic business.industry Human immunodeficiency virus (HIV) HIV Infections Odds ratio medicine.disease_cause Sensitivity and Specificity Likelihood ratios in diagnostic testing In vitro diagnostic Serology Infectious Diseases Pooled analysis ROC Curve Virology Meta-analysis Internal medicine Odds Ratio medicine Humans business |
| Zdroj: | Journal of Clinical Virology. 146:105047 |
| ISSN: | 1386-6532 |
| DOI: | 10.1016/j.jcv.2021.105047 |
| Popis: | Efficient and fast detection of HIV infection is required to make the diagnosis more robust. Use of in vitro HIV diagnostic assays based on different methods are growing rapidly. To maintain quality and further upgradation, regular performance evaluation is required. Due to presence of huge number and types of commercially available kits, choice of implementation varies differentially. The present systematic review and meta-analysis is aimed to address the diagnostic performance of commercially available in vitro HIV assays in terms of pooled sensitivity, specificity, Positive Likelihood Ratio, Negative Likelihood Ratio, area under hierarchical summary receiver operating characteristic curve and diagnostic odds ratios, in global scenario. Total of 18 articles with 35 in vitro diagnostic serological assays including 29,713 samples were subjected for the present pooled analysis. In spite of higher heterogenicity [I2 = 93.5%, Q = 520.95, df = 34 (p = 0.0000), τ2 = 9.7464], the pooled sensitivity and specificity of the diagnostic serological assays were observed ≥ 98%. |
| Databáze: | OpenAIRE |
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