Exenatide once weekly slows gastric emptying of solids and liquids in healthy, overweight people at steady-state concentrations
| Autor: | Chinmay S. Marathe, Liza K. Phillips, Tongzhi Wu, Christopher K. Rayner, Kylie Lange, Julie E. Stevens, Seva Hatzinikolas, Hung Pham, Charles H. Malbert, Michael Horowitz, Lian Q. Huynh, Karen L. Jones, Rachael S. Rigda |
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| Přispěvatelé: | Adelaide Medical School [Australia], University of Adelaide, Royal Adelaide Hospital, US 1395 ANI-SCAN [INRA], Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Royal Melbourne Institute of Technology University (RMIT University), AstraZeneca Pty Ltd., University of Adelaide William T Southcott Research Fellowship, Royal Adelaide Hospital Research Committee Florey Fellowship, NHMRC, Royal Adelaide Hospital Research Committee Postdoctoral Fellowship |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Placebo Glucagon 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Internal Medicine medicine Humans Insulin 2. Zero hunger Gastric emptying C-Peptide business.industry Area under the curve glycaemia [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Middle Aged Overweight medicine.disease Postprandial Period 3. Good health Postprandial Gastric Emptying Exenatide Female type 2 diabetes business medicine.drug |
| Zdroj: | Diabetes, Obesity and Metabolism Diabetes, Obesity and Metabolism, Wiley, 2020, 22 (5), pp.788-797. ⟨10.1111/dom.13956⟩ |
| ISSN: | 1463-1326 1462-8902 |
| DOI: | 10.1111/dom.13956⟩ |
| Popis: | International audience; Aims: To evaluate the effects of 8 weeks’ administration of exenatide (EXE) once weekly on gastric emptying of solids and liquids (using the “gold standard” technique, scintigraphy), glucose absorption and postprandial glycaemia in healthy people.Material and methods: A total of 32 healthy participants were randomized to receive either EXE once weekly (2 mg/wk subcutaneously; six men, 10 women, mean age 59.9 ± 0.9 years, mean body mass index [BMI] 29.6 ± 0.6 kg/m2) or matching placebo (PBO; six men, 10 women, mean age 60.6 ± 1.2 years, mean BMI 29.5 ± 1.0 kg/m2) for 8 weeks. Gastric emptying, nausea (visual analogue scale), and plasma glucose, insulin, C-peptide and glucagon were measured for 120 min after a solid/liquid meal, comprising 100 g ground beef (radiolabelled with 20 MBq 99mTc-sulphur colloid) and 150 mL 10% glucose (radiolabelled with 7 MBq 67Ga-EDTA), and containing 5 g 3-O-methyl-glucose (3-OMG) as a marker of glucose absorption, at baseline and after 8 weeks’ treatment.Results: The study treatments were well tolerated. Scores for nausea were consistently low, with no difference between the EXE once weekly and PBO groups. EXE once weekly slowed gastric emptying of solids (area under the curve [AUC]0–120min: P |
| Databáze: | OpenAIRE |
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