Shell Cross-linking of Cyclodextrin-Based Micelles via Supramolecular Chemistry for the Delivery of Drugs
| Autor: | Martina H. Stenzel, Yoseop Kim, Firdaus Yhaya, Sandra Binauld |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Polymers and Plastics Cell Survival Polymers Supramolecular chemistry Albendazole Micelle Polymerization Supramolecular assembly Drug Delivery Systems Cell Line Tumor Polymer chemistry Materials Chemistry Copolymer Humans Micelles chemistry.chemical_classification Acrylamides Drug Carriers Cyclodextrin beta-Cyclodextrins Organic Chemistry technology industry and agriculture Chain transfer Cross-Linking Reagents chemistry Drug carrier |
| Zdroj: | Macromolecular Rapid Communications. 33:1868-1874 |
| ISSN: | 1022-1336 |
| DOI: | 10.1002/marc.201200473 |
| Popis: | A block copolymer based on poly(N-isopropyl acrylamide) (PNIPAAm) and a block with a statistical distribution of poly(2-hydroxyethyl acrylate) (PHEA) and repeating unit with carrying β-cyclodextrin was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization and click reaction. Addition of poly(2-hydroxyethyl acrylate-s-adamantylmethyl acrylate) P(HEA(17) -s-AdMA(7) ) above the LCST of the block copolymer led to capture of the micelle structure of 36 nm against disassembly. The drug- (albendazole) loaded supramolecular assembly, which was fixed via host-guest complexation between β-cyclodextrin and adamantane, was then tested as a drug carrier. Cell viability studies using human ovarian carcinoma cell line (OVCAR-3) cell lines show a higher toxicity of the shell cross-linked micelle compared with the free block copolymer. |
| Databáze: | OpenAIRE |
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