Clinical Subtypes of Premenstrual Syndrome and Responses to Sertraline Treatment
| Autor: | Hui Lin, Steven J. Sondheimer, Karl Rickels, Mary D. Sammel, Ellen W. Freeman |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Serotonin reuptake inhibitor Individualized treatment Placebo Article Premenstrual Syndrome Young Adult Sertraline Internal medicine medicine Humans Psychiatry Mood Disorders business.industry Obstetrics and Gynecology Secondary data Middle Aged medicine.disease Antidepressive Agents Confidence interval Clinical trial Female business Premenstrual dysphoric disorder medicine.drug |
| Zdroj: | Obstetrics & Gynecology. 118:1293-1300 |
| ISSN: | 0029-7844 |
| DOI: | 10.1097/aog.0b013e318236edf2 |
| Popis: | OBJECTIVE To estimate response of diagnosis and symptom-based subtypes to sertraline treatment. METHODS This was a secondary data analysis for women who were diagnosed with premenstrual syndrome (PMS) or premenstrual dysphoric disorder and treated in three National Institutes of Health-supported clinical trials (N=447). Three PMS subtypes were identified based on predominance of psychological, physical, or both symptom types. Scores for each symptom and a total premenstrual score at baseline and endpoint were calculated from daily symptom diaries. Change from baseline after three treated menstrual cycles (or endpoint if sooner) was estimated using linear regression models adjusted for baseline severity. RESULTS The PMS and premenstrual dysphoric disorder diagnoses improved similarly with sertraline relative to placebo, whereas symptom-based subtypes had differential responses to treatment. The mixed symptom subtype had the strongest response to sertraline relative to placebo (Daily Symptom Rating difference 33.80; 95% confidence interval [CI] 17.16-50.44; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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