Long-term course and outcome in schizophrenia: a 34-year follow-up study in Alberta, Canada
| Autor: | Angus H. Thompson, Roger C. Bland, Stephen C. Newman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Hospitals Psychiatric Male Pediatrics medicine.medical_specialty Severity of Illness Index Alberta Cohort Studies Disability Evaluation Severity of illness medicine Humans Longitudinal Studies Prospective Studies Sex Distribution Prospective cohort study Psychiatry Applied Psychology Retrospective Studies Psychiatric Status Rating Scales business.industry Retrospective cohort study Middle Aged medicine.disease Outcome (probability) Term (time) Hospitalization Psychiatry and Mental health Schizophrenia Cohort Female Schizophrenic Psychology business Social Adjustment Follow-Up Studies Cohort study |
| Zdroj: | Psychological Medicine. 42:2137-2143 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291712000177 |
| Popis: | BackgroundThe aim of this study was to extend an earlier retrospective cohort study of schizophrenia via a prospective study to a follow-up of 34 years, with an emphasis on describing the life-course of the illness.MethodSubjects were 128 first-ever admissions for schizophrenia in 1963 to either of two mental hospital in Alberta, Canada. Follow-up continued until death or 1997. A symptom severity scale, with scores ranging from 0 (no symptoms) to 3 (hospitalized), was used to collect time-series data on each subject and create life-course curves. Indices were constructed to summarize the information in each curve. Information on social functioning was also collected.ResultsResults were similar for men and women. The life-course curves showed marked variability of symptom severity across subjects and over time. The average score over the entire period of follow-up for the cohort indicated ‘moderate’ symptoms, and the change in average score from beginning to end of follow-up demonstrated a slight worsening of symptoms. The measures of social functioning indicated that only about one quarter of the patients had a good to excellent outcome.ConclusionsThe long-term course in schizophrenia is one of varying symptom severity, and for many patients, there is a poor overall outcome. |
| Databáze: | OpenAIRE |
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