Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions
| Autor: | Markus Schwaiger, Tareq Ibrahim, Alexander Hapfelmeier, Christoph Rischpler, Adnan Kastrati, Christian Bradaric, Salvatore Cassese, Karl-Ludwig Laugwitz, Florian Weis, Karl P. Kunze, Massimiliano Fusaro, Stephan G. Nekolla, Teresa Vitadello, Nicolas Langwieser, Thorsten Lewalter |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Percutaneous
Medizin 030204 cardiovascular system & hematology Total occlusion 030218 nuclear medicine & medical imaging 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Wall motion medicine.diagnostic_test business.industry Heart Magnetic resonance imaging General Medicine Functional recovery Magnetic Resonance Imaging Mr imaging PET/MR Hybrid imaging Viability Coronary Occlusion Positron emission tomography Coronary chronic total occlusion Positron-Emission Tomography Original Article Pet mr imaging business Nuclear medicine |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging |
| Popis: | Purpose To evaluate myocardial viability assessment with hybrid 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/magnetic resonance imaging ([18F]FDG-PET/MR) in predicting left ventricular (LV) wall motion recovery after percutaneous revascularisation of coronary chronic total occlusion (CTO). Methods and results Forty-nine patients with CTO and corresponding wall motion abnormality (WMA) underwent [18F]FDG-PET/MR imaging for viability assessment prior to percutaneous revascularisation. After 3–6 months, 23 patients underwent follow-up MR to evaluate wall motion recovery. In total, 124 segments were assigned to the CTO territories, while 80 segments displayed impaired wall motion. Of these, 68% (54) were concordantly viable in PET and MR; conversely, only 2 segments (2%) were assessed non-viable by both modalities. However, 30% showed a discordant viability pattern, either PET non-viable/MR viable (3 segments, 4%) or PET viable/MR non-viable (21 segments, 26%), and the latter revealed a significant wall motion improvement at follow-up (p = 0.033). Combined imaging by [18F]FDG-PET/MR showed a fair accuracy in predicting myocardial recovery after CTO revascularisation (PET/MR area under ROC curve (AUC) = 0.72, p = 0.002), which was superior to LGE-MR (AUC = 0.66) and [18F]FDG-PET (AUC = 0.58) alone. Conclusion Hybrid PET/MR imaging prior to CTO revascularisation predicts more accurately the recovery of dysfunctional myocardium than PET or MR alone. Its complementary information may identify regions of viable myocardium with increased potential for functional recovery. |
| Databáze: | OpenAIRE |
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