Absence of Cardiac Valve Dysfunction in Obese Patients Treated with Sibutramine

Autor: Carl M. Mendel, David S. Bach, Tmila A. Pekkarinen, Weinstein Steve P, Finian Kelly, Gillian Shepherd, William F. Armstrong, Bababhai Patel, Aila Rissanen, Timothy B. Seaton
Rok vydání: 1999
Předmět:
Adult
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Aortic Valve Insufficiency
Medicine (miscellaneous)
030204 cardiovascular system & hematology
Placebo
Body Mass Index
law.invention
03 medical and health sciences
0302 clinical medicine
Endocrinology
Double-Blind Method
Randomized controlled trial
law
Weight loss
Diabetes mellitus
Internal medicine
Mitral valve
Appetite Depressants
Prevalence
medicine
Humans
Obesity
030212 general & internal medicine
Aged
business.industry
Incidence
Incidence (epidemiology)
Public Health
Environmental and Occupational Health
Mitral Valve Insufficiency
Middle Aged
medicine.disease
Echocardiography
Doppler
Color
3. Good health
Surgery
medicine.anatomical_structure
Diabetes Mellitus
Type 2
Cardiology
Female
medicine.symptom
business
Body mass index
Cyclobutanes
Food Science
Sibutramine
medicine.drug
Zdroj: Obesity Research. 7:363-369
ISSN: 1071-7323
Popis: BACH, DAVID S., AILA M. RISSANEN, CARL M. MENDEL, GILLIAN SHEPHERD, STEVEN R. WEINSTEIN, FINIAN KELLY, TIMOTHY B. SEATON, BABABHAI PATEL, TUULA A. PEKKARINEN, AND WILLIAM F. ARMSTRONG. Absence of cardiac valve dysfunction in obese patients treated with sibutramine. Obes Res. Objective: Serotonin-releasing agents prescribed as weight-loss medications have been implicated as a cause of acquired aortic and mitral valve abnormalities. Sibutramine hydrochloride (MERIDIA®) is a serotonin and norepi-nephrine reuptake inhibitor with proven efficacy of weight reduction. The purpose of this study was to determine the incidence of cardiac valve disease in sibutramine-treated patients. Research Methods and Procedures: Obese patients with type 2 diabetes mellitus enrolled in an ongoing double-blind, placebo-controlled, parallel-arm, 12-month study of sibutramine (followed by a 12-month open label extension) underwent transthoracic echocardiographic imaging and color Doppler interrogation for assessment of cardiac valve anatomy and function. Results: A total of 210 patients were evaluated. Of these, 133 were receiving sibutramine (72 in the double-blind period), and 77 were receiving placebo. The mean ± Standard Deviation age was 54±9 years, and the mean duration of treatment was 229±117 days (approximately 7. 6 months). The prevalence of left-sided cardiac valve dysfunction was low and similar for the two treatment groups (sibutramine 31133, or 2. 3%; placebo 2/77, or 2. 6%). All five cases were cases of aortic insufficiency; four were mild, one was severe (in a placebo patient). All three sibutramine cases were patients over age 50; two had a history of systemic hypertension. Conclusion: The prevalence of left-sided cardiac valve dysfunction was not higher than background in obese patients treated with sibutramine for an average of 7. 6 months.
Databáze: OpenAIRE
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