Effect of Extracellular Vesicles Formed by Multipotent Mesenchymal Stromal Cells on Irradiated Animals
| Autor: | M. Yu. Karganov, Irina Alchinova, M. V. Polyakova, Yu. S. Medvedeva, E. N. Yakovenko, I. N. Saburina |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Multipotent Mesenchymal Stromal Cells Human bone Bone Marrow Cells Extracellular vesicles General Biochemistry Genetics and Molecular Biology Andrology Extracellular Vesicles Mice 03 medical and health sciences 0302 clinical medicine Animals Humans Irradiation Cells Cultured Histological examination γ radiation Chemistry Body Weight Mesenchymal Stem Cells General Medicine Mice Inbred C57BL 030104 developmental biology Gamma Rays Differential Leukocyte Count Cytometry 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:574-579 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | C57Bl/6J mice were exposed to γ-radiation in a dose of 7.5 Gy. A week later, the experimental group received intravenous injection of extracellular vesicles isolated from the culture medium of human bone marrow multipotent mesenchymal stromal cells. Changes in the physiological parameters of animals were assessed by laser correlation spectroscopy, histological examination, cytometry, and by differential leukocyte count. In 3 and 6 weeks, the parameters of the experimental group occupied an intermediate position between the intact and irradiated groups or did not differ significantly from the parameters of the intact group. The rate and efficiency of recovery varied at different levels of organization. Reduction of damage caused by irradiation in a sublethal dose at different levels of organization of experimental animals was shown. |
| Databáze: | OpenAIRE |
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