Extinguishing extinction: hemispheric differences in the modulation of TMS-induced visual extinction by directing covert spatial attention
| Autor: | Nina Bien, Rainer Goebel, Alexander T. Sack |
|---|---|
| Přispěvatelé: | Cognitive Neuroscience, RS: FPN CN 1, RS: FPN CN 4 |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Visual perception Adolescent genetic structures Cognitive Neuroscience Attentional bias Cognitive neuroscience Neuropsychological Tests Brain mapping 050105 experimental psychology Lateralization of brain function Functional Laterality Extinction Psychological 03 medical and health sciences Young Adult 0302 clinical medicine Visual extinction medicine Humans 0501 psychology and cognitive sciences Attention Analysis of Variance Brain Mapping 05 social sciences Neuropsychology medicine.disease Magnetic Resonance Imaging Transcranial Magnetic Stimulation Visual field Visual Perception Female Cues Psychology 030217 neurology & neurosurgery Photic Stimulation Cognitive psychology |
| Zdroj: | Journal of Cognitive Neuroscience, 24(4), 809-818. MIT Press Journal of Cognitive Neuroscience |
| ISSN: | 0898-929X |
| Popis: | The topic of spatial attention is of great relevance for researchers in various fields, including neuropsychology, cognitive neuroscience, and cognitive psychology, as well as for clinical practice. Deficits of spatial attentional arising from parietal brain damage remain largely confined to the left visual field. The mechanisms underlying this hemispheric asymmetry are still elusive. We mimicked the neuropsychological syndrome of contralesional extinction by temporarily inducing a spatial attentional bias in healthy volunteers with TMS. We investigated whether directing covert spatial attention could enhance or, more importantly, counteract the resulting behavioral deficits. Although both the left and right parietal TMS induced contralateral extinction, only left hemifield extinction following right parietal TMS was severely aggravated by a competing stimulus in the ipsilesional (right) hemifield. We put forward the hypothesis that an asymmetry with respect to the ability of detaching attention from a distractor is contributing to the right hemispheric lateralization with regard to extinction. On a broader level, we suggest that “virtual patients” might be used for evaluating neuropsychological treatment in an early stage of development, reducing the burden on actual patients. |
| Databáze: | OpenAIRE |
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