Circulating cytokines reflect the expression of pro-inflammatory cytokines in atherosclerotic plaques
| Autor: | Isabel Gonçalves, Giuseppe Asciutto, Marie Mn Nilsson, Jan Nilsson, Mihaela Nitulescu, Helena Grufman, Andreas Edsfeldt, Ana Persson |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Inflammation Kaplan-Meier Estimate Sensitivity and Specificity Proinflammatory cytokine Interferon-gamma medicine Humans Cardiac and Cardiovascular Systems Chemokine CCL4 Aged Sweden Endarterectomy Carotid business.industry Chemokine CX3CL1 Tumor Necrosis Factor-alpha Plaque rupture Plasma levels Middle Aged Atherosclerosis Plaque Atherosclerotic Cerebrovascular Circulation Immunology Biomarker (medicine) Cytokines Female medicine.symptom Cardiology and Cardiovascular Medicine business Plaque inflammation Follow-Up Studies |
| Zdroj: | Atherosclerosis; 241(2), pp 443-449 (2015) |
| ISSN: | 1879-1484 |
| Popis: | Inflammation is a key factor in the development of plaque rupture and acute cardiovascular events. Although imaging techniques can be used to identify vulnerable atherosclerotic plaques, we are lacking non-invasive methods, such as plasma markers of plaque inflammation that could help to identify presence of vulnerable plaques. The aim of the present study was to investigate whether increased plasma levels of pro-inflammatory cytokines reflects inflammatory activity within atherosclerotic plaques.Cytokines were measured using Luminex immunoassay in 200 homogenized plaque extracts and plasma, obtained from 197 subjects undergoing carotid surgery. Plasma levels of macrophage inflammatory protein-1β (MIP-1β), tumor necrosis factor- α (TNF-α) and fractalkine correlated significantly, not only with plaque levels of the same cytokines but also with the abundance of several pro-inflammatory and atherogenic cytokines assessed in plaque tissue. High plasma levels (upper tertile) of MIP-1β, TNF-α and fractalkine identified the presence of a plaque with high inflammation (above median of a score based on the plaque content of MIP-1β, TNF-α, interferon-γ (IFN-γ) and fractalkine) with a sensitivity between 65 and 67% and a specificity between 78 and 83%. Furthermore, this study shows that high plasma levels of MIP-1β, TNF-α and fractalkine predict future transient ischemic attacks.Our findings show that the plasma levels of MIP-1β, TNF-α and fractalkine reflect the levels of several pro-atherogenic cytokines in plaque tissue and might be possible plasma markers for a vulnerable atherosclerotic disease. We thereby propose that these cytokines can be used as surrogate markers for the identification of patients with high-risk plaques. |
| Databáze: | OpenAIRE |
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