Surface strains in the anterior leaflet of the functioning mitral valve
| Autor: | P Shah, Hiroatsu Sugimoto, Ajit P. Yoganathan, Michael S. Sacks, Z Zeming He, S Wanant, L Lotte Baijens |
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| Přispěvatelé: | Energy Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Materials science
Surface Properties Swine 0206 medical engineering Biomedical Engineering Video Recording Strain (injury) 02 engineering and technology 030204 cardiovascular system & hematology In Vitro Techniques Plateau (mathematics) 03 medical and health sciences Motion 0302 clinical medicine Imaging Three-Dimensional Mitral valve medicine Animals Computer Simulation Leaflet (botany) Deformation (mechanics) Cardiac cycle Biomechanics Models Cardiovascular Infinitesimal strain theory Anatomy medicine.disease 020601 biomedical engineering Elasticity medicine.anatomical_structure Anisotropy Mitral Valve Stress Mechanical |
| Zdroj: | Annals of Biomedical Engineering, 30(10), 1281-1290. Springer |
| ISSN: | 0090-6964 |
| Popis: | The mitral valve ~MV! is a complex anatomical structure whose function involves a delicate force balance and synchronized function of each of its components. Elucidation of the role of each component and their interactions is critical to improving our understanding of MV function, and to form the basis for rational surgical repair. In the present study, we present the first known detailed study of the surface strains in the anterior leaflet in the functioning MV. The three- dimensional spatial positions of markers placed in the central region of the MV anterior leaflet in a left ventricle-simulating flow loop over the cardiac cycle were determined. The resulting two-dimensional in-surface strain tensor was computed from the marker positions using a C 0 Lagrangian quadratic finite element. Results demonstrated that during valve closure the anterior leaflet experienced large, anisotropic strains with peak stretch rates of 500%-1000%/s. This rapid stretching was fol- lowed by a plateau phase characterized by relatively constant strain state. We hypothesized that the presence of this plateau phase was a result of full straightening of the leaflet collagen fibers upon valve closure. This hypothesis suggests that the MV collagen fibers are designed to allow leaflet coaptation followed by a dramatic increase in stiffness to prevent further leaflet deformation, which would lead to valvular regurgitation. These studies represent a first step in improving our understanding of normal MV function and to help establish the principles for repair and replacement. © 2002 Biomedical Engineering Soci- ety. @DOI: 10.1114/1.1529194# |
| Databáze: | OpenAIRE |
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