Urethral and bladder dose-effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Autor: Veerle H. Groen, Marcel van Schie, Nicolaas P.A. Zuithoff, Evelyn M. Monninkhof, Martina Kunze-Busch, Johannes C.J. de Boer, Jochem van der Voort van Zijp, Floris J. Pos, Robert Jan Smeenk, Karin Haustermans, Sofie Isebaert, Cédric Draulans, Tom Depuydt, Helena M. Verkooijen, Uulke A. van der Heide, Linda G.W. Kerkmeijer
Rok vydání: 2022
Předmět:
Zdroj: Radiotherapy and Oncology, 167, pp. 127-132
Radiotherapy and Oncology, 167, 127-132
Radiotherapy & Oncology, 167, 127-132. ELSEVIER IRELAND LTD
ISSN: 0116-8479
0167-8140
Popis: Contains fulltext : 249595.pdf (Publisher’s version ) (Open Access) PURPOSE OR OBJECTIVES: The FLAME trial (NCT01168479) showed that by adding a focal boost to conventional fractionated EBRT in the treatment of localized prostate cancer, the five-year biochemical disease-free survival increased, without significantly increasing toxicity. The aim of the present study was to investigate the association between radiation dose to the bladder and urethra and genitourinary (GU) toxicity grade ≥2 in the entire cohort. MATERIAL AND METHODS: The dose-effect relations of the urethra and bladder dose, separately, and GU toxicity grade ≥2 (CTCAE 3.0) up to five years after treatment were assessed. A mixed model analysis for repeated measurements was used, adjusting for age, diabetes mellitus, T-stage, baseline GU toxicity grade ≥1 and institute. Additionally, the association between the dose and separate GU toxicity subdomains were investigated. RESULTS: Dose-effect relations were observed for the dose (Gy) to the bladder D2 cm(3) and urethra D0.1 cm(3), with adjusted odds ratios of 1.14 (95% CI 1.12-1.16, p
Databáze: OpenAIRE
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