First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study
| Autor: | Michelle Parlo, Kellie Dominessy, Rosemary Daly, Kristin Comella |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty adipose-derived stromal/stem cells Urology Adipose tissue Case Report autoimmune disease 03 medical and health sciences Bolus (medicine) stem cells Psoriasis Area and Severity Index Psoriasis Medicine Local anesthesia mesenchymal stem cells business.industry Mesenchymal stem cell psoriasis General Medicine Stromal vascular fraction medicine.disease stromal vascular fraction adipose tissue 030104 developmental biology cell therapy Stem cell business |
| Zdroj: | International Medical Case Reports Journal |
| ISSN: | 1179-142X |
| DOI: | 10.2147/imcrj.s163612 |
| Popis: | Background Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Video abstract |
| Databáze: | OpenAIRE |
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