First-Trimester In Utero Exposure to Methylphenidate
| Autor: | Jesper Hallas, Per Damkier, Lise Aagaard, Anton Pottegård, Dorthe Dideriksen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Pregnancy Complications/drug therapy Central Nervous System Stimulants/administration & dosage MEDLINE Attention Deficit Disorder with Hyperactivity/drug therapy Toxicology Pregnancy medicine Animals Humans Methylphenidate/administration & dosage Pharmacology Methylphenidate business.industry Infant Newborn Pregnancy Outcome General Medicine medicine.disease Pregnancy Complications First trimester Pregnancy Trimester First Attention Deficit Disorder with Hyperactivity In utero Attention deficit Central Nervous System Stimulants Female business Medicaid medicine.drug Narcolepsy |
| Zdroj: | Dideriksen, D, Pottegård, A, Hallas, J, Aagaard, L & Damkier, P 2013, ' First-Trimester In Utero Exposure to Methylphenidate ', Basic & Clinical Pharmacology & Toxicology, vol. 112, no. 2, pp. 73-76 . https://doi.org/10.1111/bcpt.12034 |
| DOI: | 10.1111/bcpt.12034 |
| Popis: | Methylphenidate is a centrally acting sympathomimetic used for the treatment of attention deficit/hyperactivity disorder in children and adolescents and for narcolepsy in adults. Despite the growing use among adult women, no reliable data on the prevalence of use during pregnancy have been published, and safety during pregnancy has not been established. We systematically reviewed available data on birth outcome after human in utero exposure to methylphenidate. Systematic searches in PubMed/Embase were performed from origin to August 2012, and data from Michigan Medicaid recipients, The Collaborative Perinatal Project and the Swedish Birth Registry were evaluated. Excluding three case reports, a total of 180 children exposed to methylphenidate in utero during first trimester were identified, among whom, four children with major malformations were observed. Methylphenidate exposure during pregnancy does not appear to be associated with a substantially (i.e. more than twofold) increased risk of congenital malformations. |
| Databáze: | OpenAIRE |
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