The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization

Autor: Zatollah Asemi, Zahra Heidar, Negar Hamzepour, Masoomeh Mirzamoradi, Shahrzad Zadeh Modarres, Esmat Aghadavod, Mohammad Hossein Pourhanifeh
Rok vydání: 2019
Předmět:
Adult
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Gene Expression
chemistry.chemical_element
Inflammation
Fertilization in Vitro
010501 environmental sciences
Placebo
01 natural sciences
Biochemistry
Inorganic Chemistry
Selenium
03 medical and health sciences
chemistry.chemical_compound
Double-Blind Method
Internal medicine
Gene expression
Humans
Medicine
Lymphocytes
0105 earth and related environmental sciences
0303 health sciences
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha
business.industry
030302 biochemistry & molecular biology
Biochemistry (medical)
General Medicine
Polycystic ovary
Clinical trial
Vascular endothelial growth factor
Endocrinology
chemistry
Dietary Supplements
Female
Tumor necrosis factor alpha
medicine.symptom
business
Infertility
Female
Interleukin-1
Polycystic Ovary Syndrome
Zdroj: Biological Trace Element Research. 193:319-325
ISSN: 1559-0720
0163-4984
2017-0513
Popis: This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Thirty-six women candidate for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They (n = 18/group) were randomly assigned into intervention groups to take either 200 μg/day of selenium or placebo for 8 weeks. RT-PCR findings indicated that selenium supplementation downregulated gene expression of interleukin-1 (IL-1) (P
Databáze: OpenAIRE
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