Identifying undiagnosed or undertreated patients with familial hypercholesterolemia from the laboratory records of a tertiary medical center
| Autor: | Zafer Tapıkara, Taner Ozgurtas, Cem Barçın, Omer Azal, Orhan Enes Tunçez, Hamza Berlik, Cihat Aytekin, Alper Sonmez, Cem Haymana, Ozlem Ozturk, Hüseyin Güzel, Yalçın Güneş |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics lcsh:Internal medicine lcsh:Diseases of the circulatory (Cardiovascular) system Delayed Diagnosis Treatment adherence lcsh:Medicine Pilot Projects Familial hypercholesterolemia Disease 030204 cardiovascular system & hematology Hospital records Medical Records Hyperlipoproteinemia Type II Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Internal medicine Surveys and Questionnaires medicine Humans 030212 general & internal medicine lcsh:RC31-1245 Lipid clinic Aged Retrospective Studies familial hypercholesterolemia business.industry lcsh:R Cholesterol LDL Middle Aged medicine.disease Coronary heart disease Telephone interview laboratory records telephone interview lcsh:RC666-701 Cardiology Female Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | Türk Kardiyoloji Derneği Arşivi, Vol 45, Iss 8, Pp 731-738 (2017) |
| ISSN: | 1308-4488 |
| Popis: | Objective: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low-density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is undiagnosed and undertreated around the world. This study aimed to examine the demographic characteristics, awareness, and treatment adherence of undiagnosed or undertreated FH patients based on laboratory records. Methods: In a 16-month retrospective survey using laboratory records, patients with elevated LDL-C (>250 mg/dL) were identified (n=395). Patients younger than 18 years of age or with secondary causes of dyslipidemia were excluded (n=98). In all, 297 patients were called and asked to participate in a phone interview regarding their demographic characteristics, awareness of dyslipidemia, and treatment adherence. Results: A total of 147 patients (mean age: 51.7+-16.6 years; 59.2% female) completed the interview. The mean LDL-C level of the patients was 292.8+-49.9 mg/dL. According to the Dutch Lipid Clinic Network criteria, 18.4% of the patients had definite FH, 66.0% had probable FH, and 15.6% had possible FH. Although the majority of the patients (93.9%) were aware of their high LDL-C level, only about half of them (n=75; 51.0%) were in treatment. Of all the patients who were interviewed, 21% (n=31) had never taken medication to lower their LDL-C, and 28% (n=41) had stopped taking a lipid-lowering drug. Conclusion: This pilot study revealed that a significant number of FH patients were not taking statins despite having a very high LDL-C level. Nationwide detection of likely FH patients using hospital records and interviewing them via a phone survey may help to better understand and manage these high-risk patients. |
| Databáze: | OpenAIRE |
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