Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults
| Autor: | Pierre Lavigne, Carolyn Pim, William Meekison, Elaine L. Mills, Bruce Smith, Paul Hasselback, Luis Barreto, David W. Scheifele, Margaret L. Russell, Robert A. Parker, Scott A. Halperin |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Microbiology (medical) Adolescent Diphtheria Toxoid Chemistry Pharmaceutical Filamentous haemagglutinin adhesin medicine.disease_cause Sensitivity and Specificity complex mixtures Double-Blind Method Confidence Intervals Tetanus Toxoid medicine Humans Vaccines Combined Child Whooping cough Aged Dose-Response Relationship Drug Tetanus business.industry Diphtheria Poliovirus Vaccination Middle Aged Toxoids bacterial infections and mycoses medicine.disease Virology respiratory tract diseases Poliovirus Vaccine Inactivated Infectious Diseases Vaccines Inactivated Antibody Formation Pediatrics Perinatology and Child Health Immunology Inactivated Poliovirus Vaccine Female Pertactin business |
| Zdroj: | The Pediatric Infectious Disease Journal. 19:276-283 |
| ISSN: | 0891-3668 |
| Popis: | Pertussis is increasingly recognized as an important cause of cough illness in adolescents and adults.To evaluate the safety and antibody response to a single dose of an adult formulation of a five component (pertussis toxoid, filamentous hemagglutinin, pertactin, fimbriae 2 and 3) acellular pertussis vaccine (aP) combined with diphtheria and tetanus toxoids (TdaP) and inactivated poliovirus vaccine (TdaP-IPV) in adolescents and adults and to assess the response to a second dose of the acellular pertussis vaccine in a subset of the adults.The study addressed 1207 healthy participants (736 adults and 466 adolescents) recruited in five Canadian communities.In a randomized, observer-blind, controlled clinical trial, adult participants received Td followed at a separate visit by aP, TdaP followed by IPV or TdaP-IPV; adolescents received Td-IPV followed at a separate visit by aP or TdaP-IPV. A subgroup of adults was given a booster of aP 1 month after TdaP.Antibody titers measured before and 1 month after each immunization; adverse events enumerated at 24 h, 72 h and 8 to 10 days.The aP vaccine given by itself was associated with adverse events less frequently than were Td, Td-IPV, TdaP or TdaP-IPV vaccines, but reaction rates did not differ significantly among the latter products. The antibody response against Bordetella pertussis antigens was vigorous in all groups, although adults given the TdaP-IPV vaccine had lower antibody titers against filamentous hemagglutinin, pertactin, diphtheria and tetanus antibodies than those given TdaP vaccine. Similarly adolescents given TdaP-IPV had lower antibody titers against pertussis toxin, filamentous hemagglutinin, fimbriae and agglutinins than those given Td-IPV and aP alone. A second dose of acellular pertussis vaccine was not associated with increased adverse events in adults but elicited increased antibody titers over that achieved by a single dose only against pertussis toxin.This adult formulation five component aP vaccine given as TdaP-IPV is safe and immunogenic in adolescents and adults and is a candidate vaccine for adolescent and adult immunization programs. |
| Databáze: | OpenAIRE |
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