Correlation of Nailfold Capillaroscopy Findings with History of Digital Ulcer on Same Finger: Results of SCLEROCAP Study

Autor: Carine, Boulon, Fanny, Velardo, Sophie, Blaise, Marion, Mangin, Joelle Decamps-Le, Chevoir, Patricia, Senet, Isabelle, Lazareth, Nathalie, Baudot, Laurent, Tribout, Bernard, Imbert, François-Xavier, Lapebie, Loubna, Dari, Philippe, Lacroix, Marie-Elise, Truchetet, Julien, Seneschal, Anne, Solanilla, Estibaliz, Lazaro, Isabelle, Quéré, Marc-Antoine, Pistorius, Julien, Asselineau, Edouard, Lhomme, Patrick, Carpentier, Joël, Constans
Přispěvatelé: Hôpital Saint-André [CHU de Bordeaux], Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Centre Hospitalier Universitaire Grenoble Alpes (CHU Grenoble Alpes), Service de dermatologie et allergologie [CHU Tenon], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Saint-Joseph, Assistance Publique-Hôpitaux de Paris, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Rangueil, CHU Toulouse [Toulouse], Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Service de rhumatologie, hôpital Pellegrin, CHU Bordeaux [Bordeaux], Service de dermatologie Hôpital Saint-André Bordeaux, Hôpital Haut-Lévêque [CHU de Bordeaux], Hôpital Saint Eloi, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Hôtel-Dieu de Nantes - Centre Hospitalier Universitaire de Nantes (Hôpital Hôtel-Dieu de Nantes - CHU de Nantes)
Rok vydání: 2022
Předmět:
Zdroj: Microvascular Research
Microvascular Research, Elsevier, 2022, 142, pp.104365. ⟨10.1016/j.mvr.2022.104365⟩
ISSN: 1556-5068
0026-2862
1095-9319
DOI: 10.2139/ssrn.4035239
Popis: International audience; Systemic sclerosis may be complicated by digital ulcers. Nailfold capillaroscopy on one finger might reflect an increased risk of digital ulcer (DU). In the present study we studied the correlations between a history of ulcer and capillary findings on the finger.Method: This study is part of Sclerocap, a multicenter study aiming at validating prospectively the prognostic value of Maricq's and Cutolo's capillaroscopic classifications during a three-year longitudinal follow-up. A history of past or present digital ulcer was recorded at inclusion and nailfold capillaroscopy was performed. Elementary findings as well as Cutolo and Maricq's classifications were assessed.Results: 387 patients were included in Sclerocap (327 females, 60 males) and 3096 fingers were examined by capillaroscopy at inclusion: 316 fingers (10%) belonging to 113 patients had a history of DU. Late Cutolo's stage was statistically correlated with a history of DU, both by univariate: OR 2.08 [1.09-3.96] and multivariate analysis: OR 1.97 [1.06-3.63]. Among the elemental abnormalities, only edema and decreased capillary density were correlated with a history of DU by multivariate analysis: respectively OR 1.92 [1.17-3.16] and 0.65 [0.49-0.85].Conclusion: This cross-sectional study in a large cohort of patients with systemic sclerosis shows a correlation between a history of digital ulcer and edema, a decrease in capillary density and the late stage in Cutolo's classification. The extent of capillary abnormalities on one finger is associated with a history of local digital ulcer. Capillaroscopy might be used to predict the risk of DU but these results need first to be confirmed by prospective studies.
Databáze: OpenAIRE
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