Coordinate Regulation of T Cell Activation by CD2 and CD28
| Autor: | Vladimir Karpitskiy, Andrey S. Shaw, Stephanie L. Kimzey, Jonathan M. Green |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
CD3 Complex
Ovalbumin T-Lymphocytes T cell Immunology CD2 Antigens Dose-Response Relationship Immunologic Antigen-Presenting Cells Epitopes T-Lymphocyte Mice Transgenic chemical and pharmacologic phenomena Cell Communication Lymphocyte Activation Mice CD28 Antigens medicine Animals Immunology and Allergy Cytotoxic T cell Mice Knockout Antigen Presentation Chemistry Immune Sera T-cell receptor CD28 hemic and immune systems Peptide Fragments Cell biology Mice Inbred C57BL medicine.anatomical_structure Solubility Signal transduction Function (biology) |
| Zdroj: | The Journal of Immunology. 164:3591-3595 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.164.7.3591 |
| Popis: | T cell activation requires co-engagement of the TCR with accessory and costimulatory molecules. However, the exact mechanism of costimulatory function is unknown. Mice lacking CD2 or CD28 show only mild deficits, demonstrating that neither protein is essential for T cell activation. In this paper we have generated mice lacking both CD2 and CD28. T cells from the double-deficient mice have a profound defect in activation by soluble anti-CD3 Ab and Ag, yet remain responsive to immobilized anti-CD3. This suggests that CD2 and CD28 may function together to facilitate interactions of the T cell and APC, allowing for efficient signal transduction through the TCR. |
| Databáze: | OpenAIRE |
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