Left atrial appendage sealing performance of the Amplatzer Amulet and Watchman FLX device

Autor: Kasper Korsholm, Anders Kramer, Asger Andersen, Jacqueline Saw, Bjarne Linde Nørgaard, Jesper Møller Jensen, Jens Erik Nielsen-Kudsk
Rok vydání: 2022
Předmět:
Zdroj: Korsholm, K, Kramer, A, Andersen, A, Saw, J, Nørgaard, B L, Jensen, J M & Nielsen-Kudsk, J E 2023, ' Left atrial appendage sealing performance of the Amplatzer Amulet and Watchman FLX device ', Journal of Interventional Cardiac Electrophysiology, vol. 66, no. 2, pp. 391-401 . https://doi.org/10.1007/s10840-022-01336-4
ISSN: 1572-8595
DOI: 10.1007/s10840-022-01336-4
Popis: Background The left atrial appendage (LAA) sealing properties of the Amplatzer Amulet and Watchman FLX devices were compared using cardiac computed tomography (CT) follow-up. Methods Single-center cohort study of patients undergoing LAAO between 2017 and 2020. Two consecutive cohorts were enrolled, one treated with the Amplatzer Amulet (n = 150) up till 2019, and a second cohort treated with the Watchman FLX (n = 150) device from 2019. Cardiac CT was performed 2 months postprocedure. The primary outcome was complete LAA occlusion defined as no visible peri-device leak (PDL) and absence of contrast patency in the distal LAA. Secondary outcomes included PDL, contrast patency without visible PDL, PDL area, and periprocedural complications. Results Complete occlusion was achieved in 39 (30.5%) of the Amulet group, compared to 89 (71.8%) of the FLX group, p 2 (59–158) and 32 mm2 (IQR 28–96) for FLX, p = 0.019. Device-related thrombosis occurred in 1 (0.7%) and 2 (1.3%), respectively (p = 0.99), with periprocedural adverse events occurring in 6 (4%) and 8 (5.3%) of the Amulet and FLX group (p = 0.79). Conclusion Complete LAA occlusion was achieved in a significantly higher proportion treated with the Watchman FLX compared to the Amulet device. PDL was smaller with the FLX than the Amulet. Conceptual device design differences make interpretation of results complex, and additional studies with clinical outcomes are needed.
Databáze: OpenAIRE
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