Tick-borne encephalitis (TBE) in Switzerland: does the prolongation of vaccine booster intervals result in an increased risk of breakthroughs?
| Autor: | Ekkehardt Altpeter, Robert Steffen, Axel J. Schmidt, Simone Graf |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pediatrics Population Immunization Secondary Antibodies Viral medicine Humans education Immunization Schedule Retrospective Studies education.field_of_study Booster (rocketry) business.industry Public health Vaccination Tick-borne encephalitis Viral Vaccines General Medicine medicine.disease Confidence interval Vaccine-preventable diseases business Encephalitis Encephalitis Tick-Borne Switzerland |
| Zdroj: | Journal of travel medicine. 29(2) |
| ISSN: | 1708-8305 |
| Popis: | Background In 2006, the Swiss Federal Office of Public Health (FOPH) decided recommending a prolongation of vaccine booster intervals after the third dose for the prevention of tick-borne encephalitis (TBE) from 3 to 10 years. Methods To ascertain whether this amendment resulted in an increased rate of vaccine breakthroughs, we conducted a retrospective analysis of surveillance data collected 2000–19 by mandatory reporting to the Swiss FOPH. Fractions of breakthroughs [with 95% confidence intervals (CIs)]—0–3 years vs >3–10 years after the third vaccination dose—were compared across time periods and age groups. Results Among 3205 notified TBE cases, known vaccination status was reported in 2562 (79.9%), including 103 patients with ≥3 vaccine doses (4.0%). Among those, there were 39 patients who had received the last dose within 3 years and 48 patients in the >3–10 years group. During the 2010–19 period in which the new booster strategy was implemented there were 23 and 38 breakthroughs, respectively, and the annual breakthrough rate was 7.7 (95% CI 5.0–11.7) cases during the first 3 years after the last dose, and 5.4 (95% CI 3.9–7.5) cases in following 7 years. We observed no significant trend of TBE breakthroughs with increasing age. Increasing numbers of TBE and of vaccine breakthroughs over time have been associated with spreading endemicity and higher vaccination coverage in Switzerland. Conclusions There is no indication that extended booster intervals resulted in an increased rate of breakthroughs, but there was a marked public health benefit with respect to increased acceptability of TBE immunization in the general population. |
| Databáze: | OpenAIRE |
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