Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study
| Autor: | Lucy J. Puryear, Helen Chong., Lauren B. Marangell, Holly A. Zboyan, James M. Martinez |
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| Rok vydání: | 2004 |
| Předmět: |
Postpartum depression
Adult medicine.medical_specialty Docosahexaenoic Acids Personality Inventory Pilot Projects Depression Postpartum Fish Oils Pregnancy Internal medicine Fatty Acids Omega-3 medicine Secondary Prevention Humans reproductive and urinary physiology Depression (differential diagnoses) chemistry.chemical_classification business.industry Fatty acid Prenatal Care medicine.disease Fish oil Eicosapentaenoic acid Psychiatry and Mental health Clinical Psychology Endocrinology Treatment Outcome chemistry Eicosapentaenoic Acid Docosahexaenoic acid Fatty Acids Unsaturated Female business Postpartum period |
| Zdroj: | Depression and anxiety. 19(1) |
| ISSN: | 1091-4269 |
| Popis: | Based on the putative relationship between depleted omega-3 fatty acids and postpartum depression, we initiated an open-label pilot study of omega-3 fatty acid supplementation with the aim of preventing postpartum depression. Euthymic pregnant females with a past history of depression in the postpartum period were started on 2960 mg of fish oil (1.4:1 eicosapentaenoic acid:docosahexaenoic acid) per day between the 34th to 36th week of pregnancy and assessed through 12 weeks postpartum. Four of seven participants had a depressive episode during the study period. No participants withdrew from the study due to adverse events. This preliminary, small, open-label pilot study failed to show promising results for the use of omega-3 fatty acid monotherapy beginning at 34 to 36 weeks gestation for the prevention of postpartum depression in patients with a prior postpartum depression history. Controlled studies are lacking. |
| Databáze: | OpenAIRE |
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