Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study
| Autor: | Gisele Queiroz Carvalho, Iúri Drumond Louro, Jerusa da Mota Santana, Marcilio Delan Baliza Fernandes, Lyvia Neves Rebello Alves, Jéssica Aflávio dos Santos, Marcos Emanoel Pereira, Eric Arrivabene Tavares, Djanilson Barbosa dos Santos, Eldamária de Vargas Wolfgramm dos Santos |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Birth weight
Physiology Single-nucleotide polymorphism Polymorphism Single Nucleotide Pregnancy outcome Cohort Studies Pregnancy Medicine Glucose homeostasis Birth Weight Homeostasis Humans Prospective Studies Prospective cohort study Child Genotyping Glucose metabolism business.industry Maternal genetics Infant Newborn Minor allele frequency Glucose Pediatrics Perinatology and Child Health Female business TCF7L2 Cohort study |
| Zdroj: | Jornal de Pediatria, Volume: 98, Issue: 3, Pages: 296-302, Published: 06 JUN 2022 Jornal de Pediatria v.98 n.3 2022 Jornal de Pediatria Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
| Popis: | Objectives To contribute to a better understanding of the maternal genetic mechanisms that influence obstetric outcomes and that are involved in maternal and child health, this study aimed to evaluate the association between maternal genetic variants and the offspring birth weight by analyzing single-nucleotide polymorphisms (SNPs) in genes related to glucose homeostasis. Methods Three polymorphisms were analyzed (GCK rs1799884, TCF7L2 rs7903146 and LEPR rs1137101) in 250 pregnant women who participated in a Brazilian prospective cohort study. Genotyping was performed by Real-Time Polymerase Chain Reaction (qPCR) using pre-designed TaqMan® SNP genotyping assays. Vitamin D dosage was performed by chemiluminescence. Variance, Pearson's chi-square test and multiple linear regression were used for the statistical analysis. Results It was possible to verify a significant association between birth weight and maternal GCK rs1799884 when obstetric outcomes, clinical and anthropometric characteristics were taken into consideration. The children of homozygous women for the minor allele GCK rs1799884 presented lower birth weight (β = -335.25, 95% CI = -669.39; -1.17, p = 0.04). Furthermore, a direct link between a leptin receptor variant and gestational duration was found (p = 0.037). Conclusion The variant GCK rs1799884 (mm) was associated with a reduction in newborn weight in the miscegenated Brazilian population. |
| Databáze: | OpenAIRE |
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