Traces of Learning in Thalamocortical Circuits
| Autor: | David J. Margolis, Alex J. Yonk |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
animal structures General Neuroscience Sensory system Somatosensory Cortex Plasticity Biology Somatosensory system Article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Thalamus medicine sense organs Neuroscience Nucleus 030217 neurology & neurosurgery Associative property |
| Zdroj: | Neuron |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2019.06.020 |
| Popis: | Neocortical circuits are sensitive to experience, showing both anatomical and electrophysiological changes in response to altered sensory input. We examined input- and cell-type specific changes in thalamo- and intracortical pathways during learning using an automated, home-cage sensory association training (SAT) paradigm coupling multi-whisker stimulation to a water reward. We found that POm, but not VPM, drives increased cortical activity after 24 hours of SAT, when behavioral evidence of learning first emerges. Synaptic strengthening within the POm thalamocortical pathway was first observed at thalamic inputs to L5 and was not generated by sensory stimulation alone. Synaptic changes in L2 were delayed relative to L5, requiring 48 hours of SAT to drive synaptic plasticity at thalamic and intracortical inputs onto L2 Pyr neurons. These data identify the POm thalamocortical circuit as a site of rapid synaptic plasticity during learning and suggest a temporal sequence to learning-evoked synaptic changes in the sensory cortex. |
| Databáze: | OpenAIRE |
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