The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection
| Autor: | Heinz Kurt Hochkeppel, Helmut Deicher, Barbara Tschechne, Ingolf Schedel, Peter Von Wussow, Michel A. Horisberger, D. Jakschies, Berthold Block |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Myxovirus Resistance Proteins Immunology Human immunodeficiency virus (HIV) Alpha (ethology) medicine.disease_cause Peripheral blood mononuclear cell Antiviral Agents Antibodies Interferon AIDS-Related Complex GTP-Binding Proteins medicine Immunology and Allergy Humans Acquired Immunodeficiency Syndrome biology business.industry Proteins Protein superfamily Virology In vitro Infectious Diseases Interferon Type I biology.protein Antibody business Intracellular medicine.drug |
| Zdroj: | AIDS (London, England). 4(2) |
| ISSN: | 0269-9370 |
| Popis: | Twenty-six people with symptomatic HIV-1 infection were screened for the presence of interferon (IFN) alpha and IFN alpha antibodies in their sera and the presence of the IFN-induced intracellular Mx-homologous protein in their peripheral blood leukocytes. Eleven people had measurable IFN alpha levels ranging from 1 to 40 IU/ml. None of the sera tested was positive for IFN alpha binding or IFN alpha neutralizing antibodies in the assays employed. Twenty-five of the 26 people had significant levels of the Mx-homologous protein in their peripheral mononuclear cells. The Mx concentrations varied from 0.3 to 6 U/ml in the people studied. IFN alpha-positive people had significantly higher levels of the Mx homolog than IFN alpha-negative people (P less than 0.03). Furthermore, the Mx homolog content in Walter-Reed class 2 people was significantly lower than in Walter-Reed class 5/6 people (P less than 0.01). Our results suggest that the IFN system is activated in more than 90% of the people with lymphadenopathy-associated syndrome, AIDS-related complex and AIDS. Since acid-labile IFN alpha can induce the Mx homolog in vitro endogenously produced IFN alpha seems likely to be responsible for the high Mx homolog levels detected. |
| Databáze: | OpenAIRE |
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