Erythropoietin Protects from Post-Traumatic Edema in the Rat Brain
| Autor: | Régine Farion, Jean François Payen, Yohan Van De Looij, Olivier Verdonck, Chantal Rémy, Gilles Francony, Christoph Segebarth, Hana Lahrech, Olivier Carle |
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| Přispěvatelé: | Neuro-imagerie fonctionnelle et métabolique (ANTE-INSERM U836, équipe 5), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dojat, Michel |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Brain Edema
Brain Edema MESH: Magnetic Resonance Imaging MESH: Recombinant Proteins 0302 clinical medicine Edema MESH: Animals 0303 health sciences Neocortex medicine.diagnostic_test traumatic brain injury MESH: Neuroprotective Agents Magnetic Resonance Imaging Recombinant Proteins 3. Good health Neuroprotective Agents medicine.anatomical_structure Neurology Anesthesia neuroprotection [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom Cardiology and Cardiovascular Medicine medicine.drug medicine.medical_specialty MESH: Rats Traumatic brain injury Neuroprotection Cerebral edema 03 medical and health sciences Internal medicine medicine Animals Humans Effective diffusion coefficient [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Rats Wistar Erythropoietin 030304 developmental biology MESH: Humans business.industry MESH: Erythropoietin Recombinant Magnetic resonance imaging MESH: Rats Wistar medicine.disease Rats Endocrinology Brain Injuries MESH: Brain Injuries Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow and Metabolism Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2007, 27 (7), pp.1369-76. ⟨10.1038/sj.jcbfm.9600443⟩ |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Erythropoietin (Epo) is gaining interest in various neurological insults as a possible neuroprotective agent. We determined the effects of recombinant human Epo (rhEpo, 5000 IU per kg bw) on brain edema induced in rats by traumatic brain injury (TBI; impact-acceleration model; rhEpo administration 30 mins after injury). Magnetic resonance imaging (MRI) and a gravimetric technique were applied. In the MRI experiments, the apparent diffusion coefficient (ADC) and the tissue T1 relaxation time were measured hourly in the neocortex and caudoputamen, during a 6 h time span after TBI. In the gravimetric experiments, brain water content (BWC) was determined in these two regions, 6 h after TBI. Apparent diffusion coefficient measurements showed that rhEpo decreased brain edema early and durably. Gravimetric measurements showed that rhEpo decreased BWC at H6 in the neocortex as well as in the caudoputamen. No significant differences in ADC, in T1, or in BWC were found between rhEpo treated-TBI rats and sham-operated rats. Our findings show that post-traumatic administration of rhEpo can significantly reduce the development of brain edema in a model of diffuse TBI. Further studies should be conducted to identify the biochemical mechanisms involved in these immediate effects and to assess the use of rhEpo as a possible therapy for post-traumatic brain edema. |
| Databáze: | OpenAIRE |
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