Macronutrient choice of BTBR.NZW mice congenic for a 21-gene region of chromosome 17
| Autor: | Jacob M. Marks, Michael G. Tordoff, Hillary T. Ellis, Samira A. Jaji |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Congenic Experimental and Cognitive Psychology Biology medicine.disease_cause Weight Gain Choice Behavior Article ITPR3 Behavioral Neuroscience Eating Food Preferences Mice Feeding behavior Animals Congenic medicine Animals Inositol 1 4 5-Trisphosphate Receptors Gene Genetics Mutation Body Weight Feeding Behavior Inositol trisphosphate receptor Chromosomes Mammalian Diet Chromosome 17 (human) Mice Inbred C57BL Data Interpretation Statistical Taste biology.protein Taste transduction Female |
| Zdroj: | Physiologybehavior. 106(4) |
| ISSN: | 1873-507X |
| Popis: | There has been scant work to investigate the mechanisms influencing macronutrient selection by mice. Here, we measured the consumption and choice of carbohydrate- and fat-containing diets by NZW/LacJ (NZW) and BTBR/T+ tf/J (BTBR) strains. We found that NZW mice voluntarily ate more carbohydrate and less fat than did BTBR mice. Mice with a BTBR background and a heterozygous (BTBR/NZW) congenic region on chromosome 17 between 25.7 and 27.5 Mb (N10 generation) or 26.7 and 27.5 Mb (N12 generation) also ate more carbohydrate and less fat than did homozygous (BTBR/BTBR) littermate controls. Of the 21 known and predicted genes in the congenic interval between 26.7 and 27.5 Mb, we raise for consideration as a causative candidate Itpr3, the inositol triphosphate receptor type 3 gene, which is a component of the GPCR-mediated taste transduction cascade. We speculate that a mutation in Itpr3 influences food choice by impairing the detection of nutrients in the macronutrient-containing diets. |
| Databáze: | OpenAIRE |
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