Potentiation of poststartle activity by conditioned fear: effects of anxiolytic and anxiogenic drugs
| Autor: | Kshama Devi, Hiremagalur J. Hrishikeshavan, Ravindranath S. Shanbhogue, Uba S. Munonyedi |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Xylazine Startle response Reflex Startle medicine.drug_class Conditioning Classical Stimulus (physiology) Fear-potentiated startle Anxiolytic Clonidine Moro reflex medicine Animals Biological Psychiatry Diazepam medicine.diagnostic_test Dose-Response Relationship Drug Classical conditioning Yohimbine Rats Inbred Strains Fear Buspirone Rats Anxiogenic Anti-Anxiety Agents Anxiety medicine.symptom Psychology Arousal Neuroscience |
| Zdroj: | Biological psychiatry. 29(7) |
| ISSN: | 0006-3223 |
| Popis: | This study was aimed at developing r simple novel technique for evaluati:g poststarfle behavior. Poststartle behavior is a global behavioral response displayed by an organism following a startle episode. It is generally be!ieved that a sudden stimulus such as loud noise will prompt a person to bend quickly, jerk his head forward, blink his eyes, and in various ways display the "startle reflex." The startle reflex is a primary, innate, and involuntary reaction (Landis and Hunt 1939), and has been viewed as one of the predisposing factors for emotional reactions, such as fear and or anxiety (Kubie 1941). Elevated startle response is associated with conditioned fear (Brown et al 1951). The augmentation of the startle reflex in presence of a cue (potentiation of startle) that has been previously paired with a shock is termed the fear potentiated startle effect (Davis and Astrachan 1978). This indicates that the startle response is increased by a central state of fear (McAllister and McAllister 1971). Potentiation of the startle episode is a strategy employed to elicit measurable effects of startle and relevant behavior, and has been used as a sensitive index of fear and anxiety (Davis et al 1979). The startle reflex, characterized by its short latency and fast motor act, is known to be sensitive to anxiolytics and anxiogenics; but the fear-potentiated startle para |
| Databáze: | OpenAIRE |
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